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Visit http://www.drkevinmangum.com for a full list of videos. Enjoy. If tissue injury is severe or chronic, and results in damage to parenchymal cells and epithelia as well as the stromal framework, or if nondividing cells are injured, repair cannot be accomplished by regeneration alone. Under these conditions, repair occurs by replacement of the nonregenerated cells with connective tissue, or by a combination of regeneration of some cells and scar formation. Repair by connective tissue deposition consists of a four step process: Formation of new blood vessels (angiogenesis) Migration and proliferation of fibroblasts Deposition of ECM (scar formation) Maturation and reorganization of the fibrous tissue (remodeling) Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins basic pathology e-book. Elsevier Health Sciences, 2017. Kumar, Vinay, et al. Robbins and Cotran pathologic basis of disease, professional edition e-book. Elsevier health sciences, 2014. https://www.amazon.com/Robbins-Cotran... https://www.amazon.com/Robbins-Basic-...