Total Synthesis of Lucidumone: A Hidden Treasure from Ganoderma 🍄 (3D Visualization) скачать в хорошем качестве

Total Synthesis of Lucidumone: A Hidden Treasure from Ganoderma 🍄 (3D Visualization)

Lucidumone, a fascinating natural product first isolated from Ganoderma fungi, is a true gift from nature. This medicinal mushroom is a rich source of meroterpenoid natural products such as cochlearol A, lingzhiol, and ganocin A. Since its discovery, chemists have been captivated by its complex bicyclo[2.2.2]octane core, challenging total synthesis, and unique bioactive properties. In this video, we will explore the latest synthetic strategies used to construct lucidumone, breaking down key steps like the intramolecular Diels–Alder reaction, Fleming–Tamao oxidation, and Wacker oxidation. We will also discuss how chiral ligands, Lewis acid catalysis, and Prins cyclization were employed to achieve high enantioselectivity and diastereoselectivity. By carefully designing starting materials and optimizing reaction conditions, researchers have successfully recreated this mushroom-derived molecule in the lab. Join me as we dive deep into the art and science of total synthesis, uncovering how chemists bring nature’s molecular masterpieces to life! ---------------------------------------------------------------------------------------------- Reference: Xian-Zhang Liao, Ran Wang, Xin Wang & Guang Li. Enantioselective total synthesis of (‒)-lucidumone enabled by tandem prins cyclization/cycloetherification sequence. Nat Commun. 15, 2647 (2024). https://doi.org/10.1038/s41467-024-46... ---------------------------------------------------------------------------------------------- Attribution: Vector graphics Designed by Freepik. http://www.freepik.com/ ---------------------------------------------------------------------------------------------- Time Code 00:00 - Intro 00:32 - Meroterpenoid Natural Products 01:44 - Retrosynthetic Analysis 02:45 - Forward Synthesis 02:49 - Creating Si-O Bond 03:52 - Intramolecular Diels-Alder Reaction 04:35 - Enantioselectivity 06:02 - Suzuki-Miyaura Coupling 06:46 - Prins Cyclization 07:46 - Fleming–Tamao Oxidation 08:20 - Wacker oxidation