Adverse Childhood Experiences - HPA axis & Brain changes (Part 3 of ACE series) скачать в хорошем качестве

Adverse Childhood Experiences - HPA axis & Brain changes (Part 3 of ACE series)

00:00:00 - Introduction 00:02:00 - Biological Mechanisms 00:05:00 - Acute Stress Response: Cortisol Pathways and Feedback Loops 00:08:00 - Cortisol’s Role in Daily Rhythm and Wake-Up Response 00:10:00 - Morning Cortisol Blunting in Childhood Maltreatment 00:13:00 - Flattened Cortisol Slope and Elevated Evening Cortisol 00:15:00 - Cortisol Dysregulation in PTSD, Depression, and BPD 00:18:00 - Blunted Cortisol Response to Social Stress 00:21:00 - Dose-Response Between ACEs and Cortisol Reactivity 00:24:00 - Childhood vs Adulthood Trauma 00:27:00 - Atypical vs Melancholic Depression 00:30:00 - CRH Elevation and Cortisol Resistance in Animal Studies 00:33:00 - Failed CRH Antagonist Trials for Depression and Anxiety 00:35:00 - Epigenetic Changes 00:38:00 - Cortisol Sensitivity and Mixed Findings 00:41:00 - Epigenetics Are Reversible 00:44:00 - Hippocampal Volume Loss from Trauma 00:47:00 - Exercise and Social Enrichment Restore Brain Function 00:51:00 - The Romanian Orphanage Study: Hope for Cognitive Recovery 00:55:00 - Partial Programs and Neuroplasticity in Youth 00:58:00 - IQ and Trauma 01:01:00 - Corpus Callosum and Amygdala Connectivity Disruptions 01:04:00 - Increased Amygdala Reactivity and Threat Perception 01:07:00 - Social Deprivation and Violence 01:10:00 - Chronic Inflammation 01:13:00 - Trauma and Reward System 01:16:00 - Addiction, Anhedonia, and the Need for Therapeutic Connection 01:19:00 - Long-Term Therapy and Social Support Change Brain Function 01:22:00 - Therapist Supervision and Resilience: Protecting the Healer Dive deep into the hidden impacts of Adverse Childhood Experiences (ACEs) in this week's episode of our enlightening series. We explore the profound and lasting effects ACEs have on the brain and body, specifically focusing on the HPA axis, inflammation, and neurobiology. Discover how early adversity shapes various psychiatric disorders and the intricate biological mechanisms behind these changes. Whether you're a mental health professional, a researcher, or simply interested in the profound ways early life experiences shape us, this episode offers invaluable insights and cutting-edge research. Don't miss out on this deep dive into the lasting impact of ACEs on our well-being. Link to Blog: https://www.psychiatrypodcast.com/psy... By listening to this episode, you can earn 1.5 Psychiatry CME Credits: https://www.psychiatrypodcast.com/cme...