Cholinergic Drugs | parasympathomimetic drugs | скачать в хорошем качестве

Cholinergic Drugs | parasympathomimetic drugs |

SR Pharmacy App Link : https://vbclnx.on-app.in/app/home?org... Join My Telegram Channel https://t.me/S_R_Pharmacy_Official Follow me on instagram   / s_r_pharmacy   My Facebook Page   / 1zfn3qvkav   Whatsapp Channel Join Now https://whatsapp.com/channel/0029VaEh... link part 1    • Pharmacology Chapter 2 Part 1|| Drugs Acti...   d Pharma second year books https://amzn.to/3PM2dvG #Cholinergic_Drugs ( #Parasympathomimeticts ) #Cholinergic Drugs are those drugs which give action similar to #acetylcholine . They give their action by directly binding to the cholinergic receptors or by indirect process . #Classification_of_cholinergic_drugs 1) Direct Acting #Cholinergic Agonist these drugs produced actions similar to ACh by directly interacting with cholinergic receptors . #Acetylcholine , #Methacholine , #Carbachol , Bethanechol. Pilocarpine . 2) Indirect Acting Agents ( #Anticholinestrase ) These drugs inhibit the enzyme cholinestrase , this enzyme inactivates the Acetylcholine . #Physostigmine ( this can cross blood brain barrier ) #Neostigmine ( this can't cross blood brain barrier ) . #Pharmacological Actions 1) #Muscarinic_Action a) Heart : bradycardia ( slow down heart rate ) b) Blood Vessels : dilates blood vessels , lowers blood pressure c) Respiratory System : bronchoconstriction d) smooth muscles : contracts smooth muscles e) Exocrine Gland : Increase secretion ( saliva ,HCL , Pancreatic Juice ) f) GI Tract : Increase peristalsis Movement . g) Urinary Bladder : Contraction h) Eye : Contraction of Pupils 2) Nicotinic Action a) Skeletal Muscle : contraction b) CNS : ACh does not cross BBB , but if injected directly into brain and stimulates initially and then depresses. #Indications #Acetylcholine is mainly used in experimental studies , and has limited clinical value because of following reasons . 1) It is rapidly hydrolysed by the #Pseudocholinesterases . 2) It spread widely and diffuses in easily and thus does not produce a selective pharmacological action . 3) It can not be administered orally as it immediately hydrolysed and degraded by gastric enzymes . #Methacoline is not used nowadays . Carbachol shows action on M and N receptors non selectively , so no longer in use . #Bethanechol Is in use as 1) In case of gastroparesis , postoperative abdominal distension . 2) In case of urinary bladder retention . Dose #Bethanechol : 5 or 10 mg tablets , 10-30 mg 3-4 times in a day . Contraindications 1) Hyperthyroidism : choline ester may precipitate cardiac arrhythmias . 2) Bronchial Asthma : choline ester may precipitate bronchospasm . 3) Peptic ulcer : choline ester may increase gastric acid secretion . 4) Myocardial Infarction : choline ester may cause hypotension and form conduction block . @SRPharmacy #cholinerguc_drugs #parasympathomimetics #pharmacologychapter2part2 #pharmacologychapter2part2bysrpharmacy #cholinergicdrugssrpharmacy #pharmacologychapter2lectue #pharmacologyimportantquestions #pharmacologychapter2newsyllabus #pharmacologylecture #pharmacology_lecture