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Clonidine Suppression Test

Clonidine suppression test has been used to diagnose pheochromocytoma and those paragangliomas that may secrete epinephrine, norepinephrine, or both. Such tumors may cause paroxysmal or persistent hypertension. The test is useful in the investigation of hypertensive patients, especially younger individuals, particularly when hypertension is paroxysmal, suggesting pheochromocytoma. It is based on the principle that clonidine suppresses normal neurogenically mediated catecholamine release, but does not affect autonomous tumor production of catecholamines. Failure to suppress plasma norepinephrine indicates autonomous release from a tumor. Reference: McHenry, C., Hunter, S., McCormick, M. et al. Evaluation of the clonidine suppression test in the diagnosis of phaeochromocytoma. J Hum Hypertens 25, 451–456 (2011). https://doi.org/10.1038/jhh.2010.78 https://www.labcorp.com/resource/clon... https://www.rcpa.edu.au/Manuals/RCPA-...