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This is the last tutorial in module 3 of Part One of this course on fluids. The tutorial will look at how fluids distribute between the intravascular and interstitial space in different circumstances. The questions that I am going to look at include: What happens to iv fluid when it is injected into veins? Where does it go? How long does it remain in the plasma or the interstitium? Does anaesthesia or the stress response influence how long fluids stay in the body and how they are distributed? Which stays in the bloodstream longer – a fast bolus or a slow bolus? @ccmtutorials www.ccmtutorials.org 0:00 Fluid Kinetics 01:30 Contents 02:20 Clinical Scenario 03:30 Volume Kinetics: One Compartment Model 05:00 The Stress Response during Anesthesia and Surgery 06:15 Clinical Scenario 2 08:00 Hemoglobin Changes During the Perioperative Period 11:10 Volume Kinetics Two Compartment Model 13:40 The Half Time of Intravenous Fluids 14:50 Fluid Infusion Awake Volunteers 17:00 Clinical Scenario 2 - fluid distribution and urinary output 18:00 Impact of Anesthesia on the Macrocirculation 22.30 Urinary Output During Surgery - varying iv volume 24:30 DIstribution of Fluid Under Anesthesia (plasma vs interstitium) 25:30 Impact of Blood Pressure on Fluid Distribution 26:50 Small Versus Large Volume Boluses and Distribution 28:45 Fluid Distribution in Low Volume States 30:45 Fluid Distributuion in High Volume States 32:00 Infusion of 200ml vs 1000ml over 10 mins - what happens? 33:40 What happens to fluid 30 minutes after the end of surgery 35.40 Detailed review of this volume kinetics