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Watch the Full Video at https://www.jove.com/v/60996/drug-scr.... Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish - a 2 minute Preview of the Experimental Protocol Meghan G. Haney, L. Henry Moore, Jessica S. Blackburn University of Kentucky, Department of Molecular and Cellular Biochemistry; University of Kentucky, Markey Cancer Center; Zebrafish xenograft models allow for high-throughput drug screening and fluorescent imaging of human cancer cells in an in vivo microenvironment. We developed a workflow for large scale, automated drug screening on patient-derived leukemia samples in zebrafish using an automated fluorescence microscope equipped imaging unit. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments