Orchestrating Cell Behavior in a Novel 3D Modular System: Ronawk | UT Dallas Bioengineering скачать в хорошем качестве

Orchestrating Cell Behavior in a Novel 3D Modular System: Ronawk | UT Dallas Bioengineering

Orchestrating cell behavior in a novel 3D Modular System Dr. A.J. Mellott, Co-Founder and CEO, Ronawk Abstract Mammalian cells have been grown in 2D for nearly 70 years, even though cells naturally grow in 3D inside organisms. The biggest advancements to the Petri dishes have been changing the material from glass to plastic, and changing the container from a dish to a flask or well. However, these advancements still utilize a 2D format. Interestingly, there has been an explosion in biomaterial science and manufacturing over the past 15 years. Scientists can now fabricate unique substrates that introduce micro fluidic components, innovative topographies, and combine multiple materials together to build “labs on a chip” to study how flow affects cell behavior across a variety of cell types. Yet, before cells are added to these innovative systems, they are still grown in 2D. Why? It’s cheap and easy. However, what if we could utilize the advancements in 3D printing and biomaterial science to start growing cells in 3D earlier? Would this not provide more accurate insights to cell behavior? At Ronawk, we think so. That is why we are working with scientists to modernize the Petri dish, and have created Bio-Blocks™. We have created a scaffold system that is modular, hydrogel-based, and able to couple together to help scientists grow cells more efficiently and naturally. Our Bio-Blocks have been manufactured to produce higher quality cells for researchers while by-passing the need to sub-culture, so scientists can spend more time on high impact experiments rather than growing cells. A.J. Mellott, Ph.D. CEO and Co-Founder, Ronawk He/Him/His Dr. A.J. Mellott earned his doctorate in Bioengineering from the University of Kansas in 2014, where he focused on genetically reprogramming human umbilical cord mesenchymal stem cells to become mechanosensory hair cells using non-viral methodologies. He went on to build a successful basic research program for the Department of Plastic Surgery at the University of Kansas Medical Center. In 2019, Dr. Mellott co-founded Ronawk to create 3D technologies that accelerate research for the development of next-generation therapies.   / a-j-mellott-b1050060   For More Information visit https://ronawk.com/