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In this foundational lecture for the College of Glycation, Dr. Paul Reynolds explains the process of glycation—how sugars spontaneously bond to proteins, fats, and DNA to form Advanced Glycation End-products (AGEs). These reactions contribute significantly to aging, chronic inflammation, and the development of major diseases. Drawing from real-world examples, historical context, and the latest scientific research, Dr. Reynolds walks through why glycation occurs, how modern diets have worsened its impact, and what strategies can help mitigate it. This video is designed to give viewers a practical, evidence-based understanding of how to protect their long-term metabolic health. Timestamps: 00:00 – Welcome to the College of Glycation 00:37 – What Is Glycation and Why It Matters 01:14 – How Glycation Happens: The Chemical Breakdown 03:11 – Blood Sugar and Glycation Acceleration 03:48 – History of Glycation and the Maillard Reaction 04:23 – Glycation and Disease: A1C, Aging, and More 05:48 – Eating AGEs: Processed Food and Diet Trends 06:33 – What the Science Says: Cell and Human Studies 08:32 – The Glycation-Sugar Connection 09:13 – Carbs, Fructose, and Modern Diets 10:32 – Ketosis: An Anti-Glycation Strategy 11:52 – Consequences of Glycation: Organs and Aging 13:09 – Oxidative Stress and the Glycation Feedback Loop 13:52 – What You Can Do: Diet and Lifestyle Solutions 14:31 – Final Thoughts and Next Steps Topics Covered -The chemical process of glycation and the formation of AGEs -The historical discovery of glycation and its relevance to human health -Research findings on glycation’s role in inflammation, diabetes, cardiovascular disease, and neurodegeneration -How modern diets increase glycation through carbohydrate and fructose intake -The benefits of ketosis and low-carbohydrate strategies for reducing glycation -Practical approaches to minimize glycation through diet and lifestyle About Dr. Paul Reynolds Dr. Paul Reynolds is a Professor of Cell Biology and Physiology at Brigham Young University. Known for his clarity in teaching complex biomedical concepts, Dr. Reynolds bridges cutting-edge research with practical health education. Through the College of Glycation series, he aims to make advanced metabolic science accessible and actionable for a broad audience. For more on glycation, metabolic health, and preventative strategies, subscribe to this channel and continue learning through the College of Glycation series. Questions or suggestions? Leave a comment below. #CollegeOfGlycation #DrPaulReynolds #Glycation #AGEs #MetabolicHealth #Healthspan #LowCarb #Ketosis #CellBiology #ChronicDiseasePrevention