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https://amuzainc.com When comes to neurotransmitter detection such as: Dopamine, Serotonin, Norepinephrine, Glutamate, GABA, Acetylcholine, etc. In microdialysis samples, tissue homogenates, blood plasma, and others, there are three (3) main methods; LC-Mass Spectrometry (LC-MS), HPLC-ECD (Electrochemical Detection) & ELISA/Radioimmunoassays. The first option is LCMS, it provides the highest sensitivity and specificity to the detecting neurotransmitters and also the most expensive option. The price range is between around US$200,000 to $600,000. The second method is HPLC-ECD which is much more cost affordable with offering great sensitivity. The price range is between US$20,000 to $60,000. The third method is ELISA or Radio Immuno Assays which offers less sensitivity. There is also a concern of selectivity due to cross talk of antibody. Therefore, when choosing which method would work best for you, we would recommend HPLC-ECD.