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Explore the intricate classification of B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) in this detailed video designed for pathology residents, fellows, hematologists, hematooncologists, and healthcare professionals. Enhance your understanding of genetic abnormalities and their diagnostic significance in B-ALL/LBL. In this video, we cover: Genetic Abnormalities Identified by Cytogenetic Techniques: Aneuploidy and recurrent rearrangements including hyperdiploidy, hypodiploidy, BCR::ABL1 fusion, KMT2A rearrangements, TCF3::PBX1 fusion, TCF3::HLF fusion, and IGH::IL3 fusion. FISH-Detected Genetic Abnormalities: ETV6::RUNX1 fusion and iAMP21. Transcriptomic Analysis-Defined Genetic Abnormalities: BCR::ABL1-like and ETV6::RUNX1-like features. Other Defined Genetic Alterations: DUX4, MEF2D, ZNF384, NUTM1, MYC rearrangements, and PAX5 alterations including PAX5 p.P80R. Gain valuable insights into the molecular landscape of B-ALL/LBL and stay at the forefront of hematopathology research. Don't forget to like, comment, and subscribe for more educational content! 👍🔔 #BLymphoblasticLeukemia #Hematopathology #GeneticClassification #MedicalEducation #PathologyTraining #Hematology #Oncology #HealthcareEducation #LeukemiaAwareness