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The Affinity Advantage

Drug discovery is a complex, multi-parameter optimization process. While many properties must be balanced, optimizing drug-receptor binding affinity remains essential, and its potential to accelerate discovery is often underappreciated. In this Flash Talk, Mark Murcko, Senior Lecturer at MIT and Principal of Disruptive Biomedical LLC, will discuss how affinity optimization provides distinct benefits, including achieving potent tool compounds more quickly, increasing potency and selectivity, and optimizing drug candidates more efficiently. He will also share a practical checklist of suggestions to help project teams address the challenges of affinity optimization while balancing on-target engagement, chemical diversity, and minimizing interactions with “avoid-ome” targets. 00:00 Welcome and Introduction 11:19 Full Text Search 13:15 Presentation 43:04 Q&A If your company doesn’t have a subscription yet, reach out here to inquire about access: https://drughunter.com/plans Recorded on March 5th, 2026, as a Drug Hunter Flash Talk. Sign up to be notified of future sessions here: https://drughunter.com/flash-talk-ser... Sign up for our free newsletter here: https://drughunter.com/newsletter-sig...