Inside Monash: Redefining GPCR Drug Discovery with Dr. Michelle Halls | 176 скачать в хорошем качестве

Inside Monash: Redefining GPCR Drug Discovery with Dr. Michelle Halls | 176

Inside Monash’s collaborative labs, Dr. Michelle Halls is uncovering how GPCRs achieve femtomolar sensitivity — and why receptor organization, not expression, is the next frontier in drug discovery. 👤 Meet Michelle Halls Dr. Michelle Halls is an Associate Professor at the Monash Institute of Pharmaceutical Sciences, where she co-leads the Drug Discovery Biology theme. Her research decodes how receptor organization, protein scaffolds, and cyclic AMP microdomains create specificity in signaling — and how these same systems change in cancer. From cell-level complexity to team-level collaboration, her work reveals what true innovation in GPCR pharmacology looks like. ⸻ ⏱️Timestamps 01:58 | Meet Michelle Halls — GPCRs, Monash, and Molecular Pharmacology 03:28 | A Childhood Lab Visit That Sparked a Career 05:48 | Falling in Love with Pharmacology 07:38 | GPCRs, Cambridge, and the Power of Protein Complexes 10:18 | Data is Easy, Questions are Hard 12:28 | AI, Collaboration, and the Language Gap 14:28 | Career Paths: Following Curiosity, Not a Plan 17:48 | Inside Monash: Building a Collaborative Pharmacology Ecosystem 21:28 | The PhD Program That Breaks Down Silos 24:58 | Leading a Lab: People, Projects, and Personalized Mentorship 30:28 | What’s Your Favorite GPCR? A Signal-Centric Answer 32:00 | Aha Moments: From Lipid Rafts to Femtomolar Sensitivity 37:58 | GPCRs in Disease: What Changes in Cancer Cells 41:58 | Endogenous vs Overexpressed: Why Context Matters 44:58 | Advice for Junior Scientists 47:58 | From USB Drives to Prism: The Joy of Discovery 50:18 | Title Talk: Wrapping Up with Purpose and Playfulness ⸻ 🔗 Guest Links Monash Institute of Pharmaceutical Sciences: https://www.monash.edu/mips/themes/dr... Bluesky: https://bsky.app/profile/drmlhalls.bs... LinkedIn:  / michelle-halls-4a8204109   _____ 🧠 Want more like this? Join the Dr. GPCR Premium Ecosystem to unlock exclusive episodes, practical toolkits, and early access to GPCR University content. 👉 https://www.ecosystem.drgpcr.com/gpcr... _____ Join Terry’s Corner today! Visit https://www.terrykenakin.com for expert-led, on-demand pharmacology courses, and join us at the monthly AMAs with Dr. Terry Kenakin. _____ Get to know our Partners: 👉 Celtarys Research • Company Page: https://www.ecosystem.drgpcr.com/celt... • Press Release: https://www.ecosystem.drgpcr.com/post... • Celtarys News: https://www.ecosystem.drgpcr.com/gpcr... 👉 Revvity • Company Page: https://www.ecosystem.drgpcr.com/revvity • Press Release : https://www.ecosystem.drgpcr.com/post... • pHSense Reagents: https://www.revvity.com/category/phse... • GPCR Product Portfolio: https://www.revvity.com/category/gpcr... ______ Dr. GPCR is dedicated to fostering a collaborative ecosystem focused on GPCRs. By connecting researchers, sharing knowledge, and facilitating partnerships, the #DrGPCR Ecosystem provides resources to support advancements in GPCR drug discovery. The ecosystem encompasses a range of initiatives aimed at informing and engaging the scientific community, including courses, news updates, and networking opportunities. 🧭 Dr GPCR Links & Resources • Dr. GPCR Ecosystem: https://www.ecosystem.drgpcr.com/ • Membership & Pricing: https://www.ecosystem.drgpcr.com/univ... • Weekly News: https://www.ecosystem.drgpcr.com/gpcr...