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DOES INCREASING THE STEM SIZE OF A CEMENTED POLISHED TAPERED STEM INCREASE THE RISK OF PERIPROSTHETIC FRACTURE? Andrew Gardner Authors A. Gardner, M. Sangster, J. Mutimer, R. Barksfield Institution Gloucestershire Hospitals NHS Foundation Trust Abstract Background Periprosthetic fracture (PPF) is major complication of total hip replacement (THR). The CPT stem is associated with a higher risk of PPF. The aim was to investigate an association between increasing CPT stem size and PPF risk. Method Patients receiving a THR from 2014 – 2020 was obtained from the National joint registry and linked to local patient data on PPF. A logistic regression model was used to produce an outcome measure of PPF risk with increasing stem size (0-5) Results There was a total of 4,258 THRs of which 45 had a PPF. 84% of patients had a Vancouver B2 fracture. The highest PPF risk was seen in stem size 2 XEXT (2.69%). A multivariate model, adjusting for indication and age, indicated an increased risk in PPF as CPT stem size was increased (OR 1.32, 95% CI 1.01 - 1.75). Conclusion Increasing CPT stem size appears to increase the risk of PPF. Implant design and system limitations are two explanations for the observed association.