INTRACELLULAR ACCUMULATIONS: LIPIDS- Fatty Change скачать в хорошем качестве

INTRACELLULAR ACCUMULATIONS: LIPIDS- Fatty Change

A series of video tutorials discussing the topics for undergraduates in Pathology In this tutorial , i have discussed Intracellular accumulations- accumulation of lipids- Fatty change ***Follow me**** http://ilovepathology.com/ Twitter :   / vijaypatho     / ilovepathology2   Facebook:   / ilovepathology   • Intracellular accumulations • Overview • Intracellular accumulation of lipids • Accumulation of Neutral fat (a triester of fatty acids and glycerol ) :Fatty change • Accumulation of cholesterol and cholesterol esters. • Manifestation of metabolic derangement • Accumulation may be transient & reversible or permanent. Effects: range from harmless to toxic FATTY CHANGE • Steatosis • Fatty metamorphosis • Intracellular accumulation of neutral fat(triglycerides) within the parenchymal cells. • Common in liver • Can occur in heart, skeletal muscle and kidneys. CAUSES • ALCHOL ABUSE • - Diabetes mellitus • - Obesity • - Protien Malnutrion (starvation) • -Drugs/toxins • -Anoxia/Hypoxia • -Pregnancy Other Lipid Accumulations • Cholesterol and cholesterol esters • In atherosclerosis, cholesterol accumulates in smooth muscle cells and macrophages in the intima of arteries • In hereditary hyperlipemia, cholesterol accumulates in macrophages, usually under the skin, forming tumor-like structures known as xanthomas ~-~~-~~~-~~-~ Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"    • NEOPLASIA 6: WARBURG EFFECT: Hallmark of  ...   ~-~~-~~~-~~-~