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Nicotine is a molecule which occurs naturally in tobacco leaves as well as in certain plants, such as tomatoes and eggplants. A member of the alkaloid family, it is a natural insecticide and a cardiac stimulant in small doses. Rapidly eliminated by the body, nicotine is non-carcinogenic but toxic in heavy concentrations. It may generate dependence in the case of regular consumption. In an ordinary cigarette, it is the principal reason why smokers get addicted to cigarettes, but, contrary to popular misconception, it is not harmful in this form, which is not the case with the tars and other additives added by cigarette manufacturers. In an e-liquid, its presence provides the perception of the “hit” (contraction of the larynx during the passage of the smoke or vapour) craved by smokers.