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Acetaminophen

Mostly widely known as Tylenol, acetaminophen surpassed aspirin in sales in the 1980s. Throughout most of the world acetaminophen is marketed as paracetamol. Originally synthesized in 1877 as a derivative of aniline dye, more than 1 in 4 adults take acetaminophen at least weekly. Acetaminophen may be consumed by itself or in combination with cough and cold medicines, allergy pills, sleep-promoting drugs and various analgesics. Unbeknownst to most people, the total daily dose of acetaminophen remains a potential hazard. While the current maximum daily intake should not exceed 4000 mg from all sources, the actual safe dose may be significantly lower for many individuals. Children are especially vulnerable to overdose. The correct amount of acetaminophen varies according to body weight; tablets meant for adults are inappropriate for youngsters. Adults with active or chronic impairment of liver function and those with low body weight need to lower their dose of acetaminophen. Senior citizens should follow the same advice. Unfortunately overdoses, intended or accidental, remain quite common. Too much acetaminophen leads to potentially fatal liver failure and continues to rank as a leading cause of liver transplantation.