Insulinoma Explained: Pathophysiology, Diagnosis & Treatment Made Simple! скачать в хорошем качестве

Insulinoma Explained: Pathophysiology, Diagnosis & Treatment Made Simple!

Insulinoma: Pathophysiology, Causes, Symptoms, Diagnosis, and Treatment In this video, we cover Insulinoma, a rare pancreatic neuroendocrine tumor that secretes excessive insulin, leading to episodes of hypoglycemia. This is a high-yield topic for medical students and graduates preparing for exams like the USMLE, UKMLA, NEET PG, and others. Pathophysiology and Causes Insulinomas arise from the beta cells of the pancreas, producing unregulated amounts of insulin. This leads to persistent hypoglycemia, particularly during fasting states. While most insulinomas are benign and solitary, a small percentage are associated with MEN1 syndrome or are malignant. Symptoms The classic Whipple's Triad for diagnosing insulinoma includes: Symptoms of Hypoglycemia: Such as confusion, weakness, tremors, palpitations, and even seizures. Low Plasma Glucose: During symptomatic episodes. Relief of Symptoms: Upon administration of glucose. Symptoms often appear after fasting, exercise, or prolonged intervals between meals. Diagnosis Blood Tests: Demonstrating hypoglycemia with inappropriately high insulin, C-peptide, and proinsulin levels. 72-Hour Fasting Test: The gold standard for confirming insulinoma, where hypoglycemia with high insulin is documented. Imaging: Techniques like CT, MRI, or endoscopic ultrasound to localize the tumor. Selective Arterial Calcium Stimulation Test: Used in challenging cases to locate small tumors. Treatment Surgical Resection: The treatment of choice for most insulinomas, with excellent prognosis for benign tumors. Medical Management: Includes frequent small meals and medications like diazoxide or octreotide in patients not suitable for surgery or awaiting it. Management of Hypoglycemia: Intravenous glucose and close monitoring in acute episodes. This video provides a comprehensive review of insulinoma, helping you understand its pathophysiology, clinical presentation, diagnostic approach, and management strategies. Perfect for building strong clinical knowledge and preparing for board exams! Don't forget to like, comment, share, and subscribe for more high-yield medical content. 💻X(twitter): www.twitter.com/@Wil_dMed 💻Instagram: https://www.instagram.com/wildm.edici...