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The Study of Stem Cells

Stem cells are undifferentiated cells that are pluripotent, meaning they can become many different cell types. This pluripotency has caused there to be lots of interest potential stem-cell based therapies for conditions like neurodegenerative disease or diabetes, however controversy over how stem cells are isolated still persists. In this video, Cell Signaling Technology (CST) gives you an overview on the study of stem cells. First, embryonic stem cells (ES cells) and ESC marks will be reviewed along with stem cell pluripotency regulation through expression of key transcription factors like Oct-4 and Sox2. Information about induced pluripotent stem cells (iPS cells) and CSTs StemLight Pluripotency kits shared will also be shared. Next, stem cell differentiation along the three lineage specific pathways, the ectoderm, mesoderm (which differentiate along the mesenchymal and hemangioblast pathway) and endoderm, and corresponding lineage specific markers will be discussed. Finally, and overview on how epigenetic mechanisms like acetylation and methylation remodel chromatin to regulate stem cell pluripotency will be given.