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Summary In this episode of the Future of Dermatology podcast, Dr. Faranak Kamangar and Dr. Tina Bhutani discuss the complexities of topical non-steroidal treatments, particularly focusing on Zoryve (roflumilast). They explore the role of steroids in dermatology, the innovations in non-steroidal treatments, and the importance of understanding genital psoriasis. The conversation highlights the significance of formulation in treatment efficacy and patient compliance, emphasizing the need for awareness and education in dermatological care. Takeaways Topical non-steroidals are gaining importance in dermatology. Steroids will always have a role, but their overuse is problematic. New non-steroidal treatments simplify patient care. Formulation is key to the effectiveness of topical treatments. Genital psoriasis is often overlooked but significant. Patient compliance is crucial for treatment success. Zoryve offers multiple formulations for different conditions. Understanding the mechanism of action helps in treatment selection. Education on genital psoriasis can improve patient outcomes. Innovative treatments are essential for advancing dermatological care. Chapters 00:00 - Introduction to Topical Non-Steroidals 02:25 - The Role of Steroids in Dermatology 05:58 - Innovations in Non-Steroidal Treatments 10:08 - Understanding Genital Psoriasis 12:32 - Formulations and Indications of Zoryve