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Mesenchymal stem cells, derived from sources such as the placenta and bone marrow, have been used as an experimental treatment for multiple sclerosis. Very different from the proven therapy hematopoietic stem cell transplant, mesenchymal stem cells offer the hope of a regenerative therapy, and they also have unexpected anti-inflammatory effects. But do they actually work? This video review the results of observational and randomized trials and discusses potential side effects. Intrathecal Mesenchymal Stem Cells for MS Randomized Trial (Tisch MS Center): • Intrathecal Mesenchymal Stem Cells for MS ... Successful Mesenchymal Stem Cell Trial for Progressive MS from Hadassah [IV vs. IT vs. Placebo]: • Successful Mesenchymal Stem Cell Trial for... MS: Stem Cells Won't Work: • MS: Stem Cells Won't Work Stem Cell Transplant for Multiple Sclerosis (aHSCT): • Stem Cell Transplant for Multiple Sclerosi... Does HSCT Work for MS Long-Run? [Neurologist analyzes Italian multi-center cohort study]: • Does HSCT Work for MS Long-Run? [Neurolo... Comment or ask questions below! I would be happy to answer! Subscribe on YouTube for more videos every Wednesday! Make video requests in the comments section! Selected Sources: Efficacy and safety of hematopoietic and mesenchymal stem cells in multiple sclerosis: a meta-analysis: https://www.tandfonline.com/doi/full/... Cell therapy with placenta-derived mesenchymal stem cells for secondary progressive multiple sclerosis patients in a phase 1 clinical trial: https://www.nature.com/articles/s4159... Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: a randomized, placebo-controlled, multiple-dose study: https://pubmed.ncbi.nlm.nih.gov/25891... Ultrastructural Anatomy of the Spinal Meninges and Related Structures: https://www.nysora.com/topics/anatomy... Inflammatory hypertrophic cauda equina following intrathecal neural stem cell injection: https://pubmed.ncbi.nlm.nih.gov/23740... Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat: https://www.sciencedirect.com/science... Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial: https://www.thelancet.com/journals/la... Efficacy of intrathecal mesenchymal stem cell-neural progenitor therapy in progressive MS: results from a phase II, randomized, placebo-controlled clinical trial: https://pubmed.ncbi.nlm.nih.gov/38783... Check out my book “Resilience in the Face of Multiple Sclerosis” FREE on Amazon: https://amazon.com/dp/B07WP7H5LK It's about 5 people with MS who live incredible lives, the science and psychology of resilience, mindfulness, and ho’oponopono. Paperback priced to generate $0 royalty. Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research. Follow me on twitter: / brandon_beaber Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: • Видео T he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.