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📝 All topics from Membrane Potentials and Action Potential: https://www.nonstopneuron.com/post/me... 🌐 Explore our entire animation video library: https://www.nonstopneuron.com/ ● Follow me at: • Instagram: / nonstopneuron • Facebook: / nonstopneuron Refractory Period: Absolute & Relative Refractory Period From initiation of action potential to just before repolarization is complete, no stimulus can generate a second action potential. This is called absolute refractory period. The reason for this is that the sodium channels are in inactive configuration, which cannot be opened. And they recover only after repolarization. During hyperpolarized state, a second action potential can be generated but it requires stimulus that is stronger than usual. The reason is, that the membrane is in hyperpolarized state due to continued potassium efflux, and, not all the sodium channels have recovered yet. So it requires stronger stimulus to recruit enough channels and generate action potential. Chapters: 00:00 Intro 00:04 States of Sodium Channel During Action Potential 01:55 Refractory Period 02:13 Absolute Refractory Period 03:02 Relative Refractory Period 04:00 Summary Dr Vipul Navadiya DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.