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Facility Engineering for Integrated Microbial USP and DSP Operations

This episode is to examines how facility engineering acts as the primary governor of success when moving microbial fermentation from a lab to an industrial scale. It argues that while biological strains are optimized in controlled settings, large-scale manufacturing is dictated by the physical constraints of equipment, such as oxygen transfer limits, heat removal, and the integrity of sterility boundaries. My analysis highlights that repeatable results depend on hygienic design—specifically robust cleaning and #sterilization systems—rather than just room-class standards. By treating utilities and piping geometry as active process variables, engineers can prevent common failures like biofilm buildup or utility fluctuations that hinder productivity. Ultimately, the source positions the facility itself as a reliability multiplier that determines whether a microbe can reach its full #genetic potential in a production #environment. #Bioprocess #ScaleUp and #TechTransfer, #Industrial #Microbiology, #MetabolicEngineering and #SystemsBiology, #Bioprocessing, #MicrobialFermentation, #Bio-manufacturing, #Industrial #Biotechnology, #Fermentation Engineering, #ProcessDevelopment, #Microbiology, #Biochemistry #Biochemical Engineering, #Applied #MicrobialPhysiology, #Microbial #ProcessEngineering, #Upstream #BioprocessDevelopment, #Downstream Processing and #Purification, #CellCulture and #MicrobialSystems Engineering, #Bioreaction #Enzymes #Biocatalyst #scientific #Scientist #Research _________________________________________ Timestamp Timestamp Problem Addressed 01:52 – 03:10 Utility Oversizing vs. Peak Demand Mismatch 04:15 – 05:40 Mass Transfer vs. Power Input Trade-offs 06:22 – 07:55 Downstream Bottlenecking from USP Titers 09:10 – 10:35 Contamination Transfer at the USP/DSP Interface 11:45 – 13:10 Exothermic Heat Management in USP 13:50 – 14:55 Waste Stream Neutralization Logic