Human Epidermal Melanocytes: HEM скачать в хорошем качестве

Human Epidermal Melanocytes: HEM

Human Epidermal Melanocytes undergoing normal growth in culture. Note the characteristic shape and healthy cell divisions throughout the observation period (7 days, with medium changed every other day). Right after thawing the cultures may contain cell fragments and growth media serum particles, so the debris visible in the beginning of the video is normal and expected. See also: www.cellapplications.com/primary-cells/human-epidermal-melanocytes-hem Epidermal melanocytes are pigment-producing cells located at the basal level of epidermis, where they interact with keratinocytes* via cellular processes called dendrites. Melanin, the pigment produced by melanocytes and responsible for skin color, is then transferred to keratinocytes, where it is stored in vesicles called melanosomes located around the nucleus to provide protection from UV radiation. At Cell Applications, Inc., rimary Human Epidermal Melanocytes (HEM) are isolated from normal human neonatal foreskin or adult skin. HEM are cryopreserved at second passage and can be cultured and propagated for at least 12 population doublings. The cells can be shipped frozen or proliferating, and all the media reagents are included. These epidermal melanocytes produce melanin, thus they serve as a useful cell model in the study of hyperpigmentation through accentuated melanocyte proliferation and differentiation(1,2), as well as progression of melanocytic neoplasia(3,4). 1. Jimbow, K. et al, J. Invest. Dermatol. 78:108 (1982). 2. lmokawa, G. et al, Arch. Dermatol. Res. 278:352 (1986). 3. Herlyn, M. et al, Lab. Invest. 56:461(1987) 4. Simon, H., Cancer Res. 56:3112 (1996). Matched primary cells from the same donor are available upon request Human Epidermal Keratinocytes Human Epidermal Melanocytes Human Dermal Fibroblasts Human Dermal Microvascular Endothelial Cells Each lot is tested negative for HIV, Hepatitis B and Hepatitis C and negative for mycoplasma, bacteria, and fungi. Products are for research use only. They are not intended for human, animal, or diagnostic applications. For more product information and a reference list www.cellapplications.com Follow Cell Applications, Inc. LinkedIn: www.linkedin.com/company/cell-applications-inc. Facebook: www.facebook.com/cellapplications Twitter: witter.com/cellappsinc Google+: plus.google.com/+Cellapplications