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Over the past few decades, application of immunotherapy in cancer has gone from concept to successful therapy. In particular, manipulation and modification of T-cells has led to exciting results in treating heme malignancies such as acute and chronic leukemia, lymphomas, and multiple myeloma. In particular, CAR-T therapies and bispecific antibodies have shown success in treating several such cancers and have moved from drugs of last resort to earlier lines of therapy. This panel will discuss the progress that has resulted from introduction of highly targeted bispecific antibodies, as well as cell and gene hybrid therapies such as CAR-T and will address challenges for future developments. Moderators Tim Anderson, MD, Pharmaceutical Analyst, BofA Securities Alec Stranahan, SMid-Cap Biotech Analyst, BofA Securities Speakers Amir Fathi, MD, Director, Leukemia Program, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School Connor Johnson, MD, Assistant Professor of Medicine, Massachusetts General Hospital & Harvard Medical School Rosanna Ricafort, MD VP, Head of Global Program Leadership, Hematology and Cell Therapy Drug Development, Bristol Myers Squibb Andrew Yee, MD, Clinical Director, Center for Multiple Myeloma, Mass General Cancer Center, Assistant Professor of Medicine, Harvard Medical School