EP 210: Live from ASHG: Breaking barriers in genomics with Heidi Rehm and Slavé Petrovski скачать в хорошем качестве

EP 210: Live from ASHG: Breaking barriers in genomics with Heidi Rehm and Slavé Petrovski

This week on The Genetics Podcast, recorded live at ASHG 2025, Patrick is joined by Heidi Rehm, Chief Genomics Officer at MGH’s Center for Genomic Medicine and Co-director at the Broad Institute, and Slavé Petrovski, Vice President of AstraZeneca's Centre for Genomics Research. They discuss the rapid progress of large-scale genomics, the barriers to integrating genetic data into healthcare and drug development, and how open collaboration, global data sharing, and a focus on equity are driving more inclusive and impactful genomic discovery. Show Notes: 0:00 Intro to The Genetics Podcast 00:59 Welcome to Heidi and Slavé 02:03 Slavé’s role at AstraZeneca and work in genomics-driven R&D 03:30 Heidi’s work at the Broad Institute bridging clinical genomics, rare disease research, and global data-sharing initiatives 04:24 Heidi on breaking a Guinness world record for rapid neonatal ICU (NICU) genomics and the shift to open data sharing 06:50 Slavé on how large-scale, multimodal human data is transforming genomics research 08:33 Heidi’s initiatives to integrate genomics into routine care at hospitals and with primary care physicians 12:20 Integrating genomics into clinical trials and healthcare, and enabling global discovery through AstraZeneca’s open data portal 16:20 Breaking down legal and logistical barriers to genomic data sharing and centering the patient voice 19:34 AstraZeneca’s large-scale plasma proteome study and machine learning models predicting disease onset years before diagnosis 22:46 Emerging omics tools advancing rare disease diagnosis 25:27 The value and pitfalls of AI in genomics today 30:33 Advancing health equity in genomics through data sharing, diverse recruitment, and global collaboration 35:38 Progress and challenges in next-generation genetic therapies 39:22 Reflections and advice for the next generation entering genomics and data-driven medicine 43:04 Audience Q&A 55:33 Closing remarks Please consider rating and reviewing us on your chosen podcast listening platform! https://drive.google.com/file/d/1Bp2_...