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Introduction: Dr. Brenda Weigel, MD MSc - Professor, University of Minnesota Director of the Division of Pediatric Hematology/Oncology Lehman/Children’s Cancer Research Fund Endowed Chair in Pediatric Cancer, Co-Director of the Sarcoma Program for the Masonic Cancer Center, Associate Director of the Cancer Experimental Therapeutics Initiative for the Masonic Cancer Center. Researcher, U of M, Ast. Professor Beau Webber, PhD: Identification of novel drivers of Ewing Sarcoma through engineered transformation of cells with differing levels of African admixture Researchers, U of M, Professor Amy Skubitz, PhD, Professor Keith Skubitz, MD: Predicting Relapse and response to chemotherapy in sarcoma Researcher and Oncologist, Mayo Clinic Rochester, MN - Brittany Siontis, MD: Pilot Study of Circulating Free Cell Tumor DNA as a Biomarker in Sarcoma Researcher U of M, Ast. Professor Aaron Sarver, PhD Institute of Health Informatics: Retrospective ad Prospective Comparison of Prognostic Transcriptional Biomarkers in Osteosarcoma using Nanostring RNA profileing Kelsey Becklin, (PhD Student) My research focuses on generating new models of Ewing sarcoma (ES), an aggressive type of pediatric cancer, using induced pluripotent stem cells (iPSC) and genetic engineering strategies. iPSCs provide a unique opportunity to address some fundamental questions surrounding ES etiology, such as the role genomic context (ancestry) plays on the susceptibility of ES and identifying the cell-of-origin through the development of a novel system, inducing the native translocation. Janelle Calhoun, Executive Director, Rein in Sarcoma - Background