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Tail Suspension Mode

🎥 Simulating Microgravity in Mice: Tail Suspension Model in Action The hindlimb unloading (HU) mouse model—also known as the tail suspension model—is a widely used experimental setup to simulate the physiological impacts of microgravity or mechanical unloading. 🔬 How It Works: Mice are suspended by the tail at a ~30° angle, keeping forelimbs in contact with the ground and hindlimbs completely unloaded. This mimics spaceflight-induced effects like: Skeletal muscle atrophy Bone loss Cardiovascular dysfunction 🧪 Key Readouts: Muscle Atrophy: Wet weight, fiber CSA, and MyHC expression of hindlimb muscles (e.g., soleus) Bone Loss: Micro-CT for BMD and trabecular structure of femur/tibia Cardiovascular Changes: Blood pressure, echocardiography, endothelial function Metabolism & Inflammation: Serum/tissue analysis of oxidative stress markers (MDA, SOD) and cytokines (IL-6, TNF-α) 🚀 Applications: Widely adopted in space medicine, this model supports the development of countermeasures (e.g., exercise, pharmacology) against microgravity-induced deterioration. It also holds significant value in orthopedics and rehabilitation medicine. #SpaceMedicine #Microgravity #PreclinicalResearch #TailSuspensionModel #MuscleAtrophy #BoneLoss #CardiovascularHealth #TranslationalMedicine #BiomedicalResearch #HUmodel #neuroscience #preclinicalresearch #brainresearch www.softmaze.com