71: The Truth About Lactate: It’s Not What You Think with Dr. Ben Bikman скачать в хорошем качестве

71: The Truth About Lactate: It’s Not What You Think with Dr. Ben Bikman

Learn more about becoming an Insider on my website: https://www.benbikman.com In this week’s episode of The Metabolic Classroom, Dr. Ben Bikman clarifies misconceptions about lactate metabolism, emphasizing that there is no lactic acid in the human body—only lactate. He explains that lactate is the end product of non-oxidative glycolysis, produced when cells, particularly muscles and red blood cells, require quick ATP energy. Dr. Bikman highlights that lactate production occurs during high-intensity activities where energy demand exceeds the capacity of mitochondria to generate ATP efficiently. Contrary to popular belief, lactate is not responsible for muscle soreness or fatigue. Ben delves into the history of lactate research, mentioning key contributors like Otto Meyerhoff, who identified lactate as a product of anaerobic metabolism, and Carl and Gerty Cori, who discovered the Cori cycle. This cycle demonstrates how lactate is recycled by the liver into glucose, which can then be used by muscles for energy. Lactate, once considered a waste product, is now understood to be an essential substrate for gluconeogenesis. Dr. Bikman introduces George Brooks' lactate shuttle theory, which reveals that lactate is a viable energy source that can be directly utilized by mitochondria for fuel. He explains that this discovery revolutionized the understanding of lactate, showing it can be oxidized within cells for energy production rather than merely being excreted as a waste product. Dr. Bikman also discusses lactate’s potential in clinical contexts, such as traumatic brain injury (TBI) recovery, where lactate can serve as an alternative energy source for the brain when glucose metabolism is impaired. Moreover, he touches on how lactate influences fat cells, promoting mitochondrial uncoupling and aiding in fat burning, contributing to metabolic health. Ben suggests that continuous lactate monitoring could help identify mitochondrial dysfunction and predict type 2 diabetes risk. https://www.insuliniq.com 00:00 - Introduction to Lactate Metabolism 01:09 - Lactic Acid vs. Lactate: Debunking the Myth 02:16 - Glycolysis and Lactate Production 04:23 - How Lactate is Produced in Muscles 06:23 - Red Blood Cells and Lactate 07:18 - History of Lactate Research: Otto Meyerhoff 09:40 - The Cori Cycle: Lactate Recycled into Glucose 13:54 - Lactate as a Viable Energy Source 15:55 - George Brooks' Lactate Shuttle Theory 18:44 - Lactate and Traumatic Brain Injury (TBI) 20:55 - Lactate’s Role in Fat Burning and Mitochondria 23:58 - Lactate in Clinical Contexts: Metabolic Health 25:09 - Continuous Lactate Monitoring and Mitochondrial Dysfunction 28:59 - Lactate as a Predictor of Type 2 Diabetes 29:59 - Conclusion: Lactate’s Critical Role in Health and Energy Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) References: Due to YouTube’s character length constraints, references are not posted here. However, for a complete list, we respond quickly. Please email: [email protected] with your request, and be sure to mention which Metabolic Classroom episode you are referring to. #Lactate #Metabolism #DrBenBikman #Bioenergetics #CoriCycle #LactateShuttle #FatBurning #Mitochondria #MetabolicHealth #Type2Diabetes #EnergyProduction #ExerciseScience #TraumaticBrainInjury #LactateMonitor #CellBiology #KrebsCycle #GlucoseMetabolism #NonOxidativeGlycolysis #InsulinResistance #HealthEducation