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Do you have trust issues? We do, too. There is a lot of research out there, both good and bad, and the difference between reliable and not-so-reliable research typically comes down to one thing—study design. Using recent real-world examples, like the first-ever retraction in JAVMA’s 180-year history, join us as we expose the critical differences between well-designed studies and those that fall short. Related Episodes Incidence episode: https://bsmpartners.net/barking-mad-p... Lit Review episode: https://bsmpartners.net/barking-mad-p... Examples of Poorly Designed Research More on the JAVMA retraction: https://www.petfoodprocessing.net/art... The Effects of Feeding Pulse-Based, Grain-Free, Diets on Digestibility, Glycemic Response, and Cardiovascular Health In Domestic Dogs: https://harvest.usask.ca/items/a96ed2... Development of plasma and whole blood taurine reference ranges and identification of dietary features associated with taurine deficiency and dilated cardiomyopathy in golden retrievers: A prospective, observational study: https://pubmed.ncbi.nlm.nih.gov/32413... (Check out the Expression of Concern for this one: https://pmc.ncbi.nlm.nih.gov/articles...) Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets: https://journals.plos.org/plosone/art... Responses in randomised groups of healthy, adult Labrador retrievers fed grain-free diets with high legume inclusion for 30 days display commonalities with dogs with suspected dilated cardiomyopathy: https://bmcvetres.biomedcentral.com/a... DCM Research by BSM Partners Blood parameters research: https://onlinelibrary.wiley.com/doi/1... Incidence paper: https://www.frontiersin.org/articles/... Board-Invited Literature Review: https://academic.oup.com/jas/article/... Show Notes 00:00 – Welcome to the Episode 03:22 – Breaking Down the Research Pyramid 09:10 – Considering All the Factors (And Controlling for Them in Research) 10:00 – What is a Literature Review, and Why is it Important? 12:47 – The Peer-Review Process and Fatal Flaws 17:07 – The FDA’s Announcement: Biased Questions Led to Biased Answers 20:46 – FDA Saves Face in Subsequent Updates 23:18 – What Goes into a Well-Designed Study? 28:20 – Nothing is Impossible, Some Things Are Just Really Hard! 32:16 – Examples of Where Research Fell Flat 35:24 – Blood Parameters don’t Tell All 38:36 – Don’t Demonize Ingredients, Instead Study Nutrients 41:19 – Full Transparency: Potential Limitations in BSM Partners’ Research 44:17 – Conclusion and Farewell