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This video examines secondary nonresponse (SNR) to botulinum toxin in aesthetic treatments, a growing concern for both practitioners and patients. Dr. George Kroumpouzos discusses the key trigger factors contributing to this phenomenon, including improper product handling, suboptimal injection techniques, and the presence of impurities within formulations. Effective management strategies are also explored, underscoring the critical role of selecting appropriate botulinum toxin formulations to mitigate the risk of nonresponse and enhance patient satisfaction. This video was recorded by the author. Read the full article here: https://derma.jmir.org/2025/1/e69960 #BotulinumToxin #AestheticTreatments #BotoxResistance #Dermatology #CosmeticInjections #Nonresponse #AestheticMedicine #MedicalEducation #BrownDerm #BrownUniversityDermatology Please cite as: Kroumpouzos G, Silikovich F Exploring Nonresponse to Botulinum Toxin in Aesthetics: Narrative Review of Key Trigger Factors and Effective Management Strategies JMIR Dermatol 2025;8:e69960 URL: https://derma.jmir.org/2025/1/e69960 DOI: 10.2196/69960 ### About JMIR Publications JMIR Publications is a leading open access publisher of digital health research and a champion of open science. With a focus on author advocacy and research amplification, JMIR Publications partners with researchers to advance their careers and maximize the impact of their work. As a technology organization with publishing at its core, we provide innovative tools and resources that go beyond traditional publishing, supporting researchers at every step of the dissemination process. Our portfolio features a range of peer-reviewed journals, including the renowned Journal of Medical Internet Research. To learn more about JMIR Publications, please visit https://www.JMIRPublications.com or connect with us via: YouTube - / jmirpublications Facebook - / jmedinternetres X - https://x.com/jmirpub BlueSky - https://bsky.app/profile/jmirpub.bsky... LinkedIn - / jmir-publications Instagram - / jmirpub Head Office - 130 Queens Quay East, Unit 1100 Toronto, ON, M5A 0P6 Canada Media Contact - [email protected] The content of this communication is licensed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/..., which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, published by JMIR Publications, is properly cited.