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Inadvertant intravenous injections

Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model https://academic.oup.com/cid/advance-... Background Post-vaccination myocarditis and pericarditis reported after coronavirus mRNA vaccines. The effect of accidental intravenous injection of this vaccine on the heart is unknown Methods in mice Compared difference between i.m. and i.v. injection of vaccine Clinical manifestations Histopathological changes Tissue mRNA expression Serum levels of cytokines and troponins With normal saline (NS) control Results Intravenous SARS-CoV-2 mRNA Vaccine Administration Induced Grossly Visible Pathology in Heart Only IV group developed histopathological changes of myopericarditis Evidenced by cardiomyocyte degeneration Apoptosis Necrosis with adjacent inflammatory cell infiltration Calcific deposits on visceral pericardium But Evidence of coronary artery or other cardiac pathologies was absent Spike antigen (immunostaining) occasionally found in infiltrating immune cells of the heart And in cardiomyocytes and intracardiac vascular endothelial cells The histological changes of myopericarditis after the first IV-priming dose persisted for 2 weeks and were markedly aggravated by a second IM- or IV-booster dose Numerous inflammatory cytokines found in cardiac tissue (interleukin (IL)-1β, interferon (IFN)-β, IL-6, and tumor necrosis factor (TNF)-α) in the IV group but not the IM group compatible with presence of myopericarditis in the IV group Ballooning degeneration of hepatocytes was consistently found in the IV group. All other organs appeared normal. Conclusions In vivo evidence that inadvertent intravenous injection of COVID-19 mRNA vaccines may induce myopericarditis. Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk. Both Pfizer/BioNTech and Moderna have clearly stated that their vaccines should only be given via IM route Current CDC and WHO guidelines no longer recommend precautionary measures during IM vaccine administration The CDC Pink Book 2020 and WHO 2015 position paper have recommended against aspiration prior to vaccine injection so as to minimize pain Deltoid to the vastus lateralis? Our study indicates that IV injection of vaccines might partially contribute to this clinical phenotype, thus warranting a reconsideration of the practice of IM injection without aspiration, which carries the risk of inadvertent IV injection. Thrombocytopenia in mice reported in 2006 Blood, (2006) https://ashpublications.org/blood/art... All mice received virus through a single tail vein injection Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors.