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In this episode of The Director’s Desk, NIH Director Dr. Jay Bhattacharya hosts a roundtable with the primary authors of the newly released HHS peer-reviewed report, “Treatment for Pediatric Gender Dysphoria: Review of Evidence and Best Practices.” This landmark review evaluates the scientific evidence behind pediatric gender dysphoria treatments — including puberty blockers, cross-sex hormones, and surgical interventions — and concludes that these “sex-rejecting procedures” carry substantial and long-term risks for children and adolescents. Featured Authors / Contributors: Evgenia Abbruzzese, Society for Evidence-Based Gender Medicine Alex Byre, PhD, Massachusetts Institute of Technology Farr Curlin, MD, Duke University Moti Gorin, PhD, MBE, Colorado State University Kristopher Kaliebe, MD, DFAACAP, University of South Florida Michael K. Laidlaw, MD, Michael K. Laidlaw MD, Inc. Kathleen McDeavitt, MD, Baylor College of Medicine Leor Sapir, PhD, Manhattan Institute for Policy Research Yuan Zhang, PhD, Evidence Bridge Other contributors involved in the peer review and evidence assessment Together, they break down the report’s major findings, discuss long-term outcomes, examine the strength and limitations of current evidence, and outline implications for clinical best practices, research, and policy. 📄 Read the full HHS report: “Treatment for Pediatric Gender Dysphoria: Review of Evidence and Best Practices” (See link in description or visit HHS.gov) 🔔 Subscribe for more science-driven conversations from NIH & HHS on medical research, public health, and policy.