Beyond Acid: How Bile Reflux Fuels Barrett’s Esophagus скачать в хорошем качестве

Beyond Acid: How Bile Reflux Fuels Barrett’s Esophagus

Barrett's esophagus is typically "blamed" on acid reflux and the solution offered is to take PPI medication. But that's not the whole story. ➡️ Click HERE to Book a Consultation: https://rootcausemedicalclinics.com/h... Call us directly: 727-335-0400 Bile reflux can be more damaging to your esophagus, proven by research. Some basic information before we dive in: Barrett's esophagus occurs after many years of reflux, acid and/or bile. It is diagnosed when the lower esophageal lining changes from its normal type of cells (squamous epithelium) to the types of cells seen in your stomach (columnar epithelium). The concern is that these cells can become pre-cancerous and then cancerous and esophageal cancer is an awful cancer to have. The earlier you begin with reflux in life raises your risk for developing Barrett's. Additional risk factors are: reflux, obesity, smoking, male, caucasian, age and having a hiatal hernia. But bile reflux is one of the strongest independent factors, therefore the reason for this video. Symptoms of Barrett's includes: heartburn, regurgitation, chest pain, difficulty swallowing, or no symptoms. It's typically diagnosed during an endoscopy. Traditional treatment is PPIs, weight loss, smoking cessation and surgery. While a scary proposition to contemplate, the risk of esophageal cancer is about 5% but it is higher once the cells have become pre-cancerous. At the pre-cancerous stage there is a successful ablation surgery but the recurrence rate is about 10% per year so it's still advantageous to be addressing root cause issues. The exciting prospects for this condition is research that if the cause of reflux is addressed, healing/stabilizing and a potential for reverting to normal tissue can occur. That's certainly something we see often with hiatal hernia and reflux. When you get to the root cause of what's causing the reflux, the esophagus has the potential to heal. Solutions Address "drivers" of bile and acid reflux including hiatal hernia, weight reduction, neutralizing bile acids (alginates are helpful), shift bill acid composition to a less toxic state with things such as taurine/glycine, milk thistle. Note: I am not diagnosing nor treating you. You will need to find a clinician to work with you. For hiatal hernia utiizing diaphragmatic breathing and stabilizing the vagus nerve are important while normalizing microbiome diversity. Protect the esophagus and stomach lining with natural agents such as DGL, aloe vera and zinc. Avoid late night eating, ultra-processed foods, sugar and alcohol. If you'd like help we're here for you. The best next step is to contact us for a consultation and then we can determine if what we do is a good fit for you. Call 727-335-0400. #guthealth #acidreflux #hiatalhernia References: Katerina Dvorak, et al., "Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett’s oesophagus" Gut 2007 Bhaskar Banerjee, et al. "Clinical study of ursodeoxycholic acid in Barrett’s esophagus patients". Cancer Prevention Research 2016 (July issue) Shaheen NJ et al. ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus. Am J Gastroenterol. 2022. Andrici J, Eslick GD. Hiatal hernia and the risk of Barrett’s esophagus. J Gastroenterol Hepatol. 2013. Wiley Online Library Eusebi LH et al. Risk factors for Barrett’s oesophagus in individuals with reflux symptoms. Aliment Pharmacol Ther. 2021. White Rose Research Online Orman ES, Shaheen NJ. Efficacy and durability of radiofrequency ablation for Barrett’s esophagus. Clin Gastroenterol Hepatol. 2013. mgh-ita.org Wani S et al. Recurrence after complete eradication peaks around 18 months. Clin Gastroenterol Hepatol. 2020; referenced in AGA EET guideline 2024. Gastro Journal Huo X et al. Deoxycholic acid causes DNA damage in Barrett’s epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011. PMC Peng S et al. UDCA increases antioxidants and prevents bile-acid DNA damage in BE. Am J Physiol Gastrointest Liver Physiol. 2014. PMC Strugala V et al. Alginate removes pepsin and bile acids from refluxate. J Pharm Pharmacol. 2009. PubMed Rohof WO et al. Alginate raft localizes to and displaces the acid pocket. Clin Gastroenterol Hepatol. 2013. CGH Journal Disclaimer: The information provided in this video is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or other qualified health provider with any questions you may have regarding your health, medical condition, or treatment options. Never disregard professional medical advice or delay in seeking it because of something you have seen or heard in this video. The views expressed are based on my clinical experience and current scientific understanding as of the date of publication. Individual results may vary.