1. Disorders of Growth | Growth Hormone Deficiency & Acromegaly | USMLE Step 2 CK | Endocrinology скачать в хорошем качестве

1. Disorders of Growth | Growth Hormone Deficiency & Acromegaly | USMLE Step 2 CK | Endocrinology

📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/conceptualmedicine 📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/conceptual_... Disorders of Growth | Growth Hormone Deficiency & Acromegaly | USMLE Step 2 CK | High-Yield Endocrinology This high-yield lecture on Disorders of Growth focuses on two major extremes of growth hormone (GH) dysregulation — GH deficiency in children and adults, and GH excess (acromegaly) in adults — both of which are frequently tested on USMLE Step 2 CK in pediatric and internal medicine scenarios. GH plays a critical role in linear growth, metabolism, and tissue maintenance, and understanding its physiologic role helps in diagnosing both short stature in children and progressive somatic overgrowth in adults. We begin by discussing GH deficiency in children, a common cause of proportionate short stature. Affected children have normal body proportions, delayed skeletal maturation, and may present with growth failure, delayed puberty, increased fat mass, and immature facial features. GH deficiency may be congenital, due to pituitary developmental anomalies, or acquired, following CNS tumors, trauma, or radiation. Diagnosis includes decreased IGF-1, failure to respond to GH stimulation tests, and imaging of the pituitary-hypothalamic axis. Treatment involves recombinant GH therapy, which can lead to remarkable catch-up growth when started early. In adults, GH deficiency may result in fatigue, decreased lean body mass, increased fat mass, dyslipidemia, and impaired quality of life, but diagnosis is more nuanced and often considered in patients with known pituitary disease. In contrast, GH excess in adults leads to acromegaly, a condition caused by GH-secreting pituitary adenomas. Because the epiphyseal growth plates are fused in adults, excess GH results in soft tissue and bone thickening, not linear growth. Patients present with coarse facial features, enlarged hands and feet, jaw enlargement (prognathism), deep voice, carpal tunnel syndrome, insulin resistance, and hypertension. On Step 2 CK, always think of acromegaly in patients with increasing shoe or ring size, or unexplained type 2 diabetes with soft tissue overgrowth. Diagnosis of acromegaly involves elevated IGF-1 levels and lack of suppression of GH during an oral glucose tolerance test (OGTT). MRI of the pituitary is done to localize the adenoma. Treatment begins with transsphenoidal surgical resection, followed by medical therapy with somatostatin analogs (octreotide) or GH receptor antagonists (pegvisomant) if surgery is incomplete. This lecture provides a comprehensive, clinically focused review of GH-related disorders, including their hormonal profiles, diagnostic workup, imaging, and management — ensuring you're ready to tackle both pediatric growth failure and adult endocrine tumors on USMLE Step 2 CK. #GrowthHormoneDisorders #GHDeficiency #Acromegaly #USMLEStep2CK #ShortStature #PituitaryAdenoma #IGF1 #EndocrinologyReview #HighYieldPediatrics #TranssphenoidalSurgery #GHStimulationTest #OGTT #WhiteboardMedicine #Step2Prep #DrGBhanuPrakash #USMLEBuzzwords #MedicalEducationUSA #TallStature #Gigantism #Hypopituitarism #EndocrineTumors #USMLE2025 #ConceptualMedicine #MedicalConcepts #NEETPGPrep #FMGE2025 #USMLE2025 #ClinicalMedicine #MBBSConcepts #NextExamPrep #MedSchoolMadeEasy #MedStudentLife #HighYieldMedicine #PathophysiologySimplified #LearnMedicineFast #VisualMedicine #MedicalMnemonics #CrackNEETPG #USMLEStep1Prep #MedEducationRevolution #MBBSShorts #DoctorInTheMaking