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*Mayur Sharma, MD,1 Daria Krivosheya, MD, FRCSC,2 Hamid Borghei-Razavi, MD, PhD,2 Gene H. Barnett, MD, MBA,2 and Alireza M. Mohammadi, MD2 1Department of Neurosurgery, University of Louisville, Kentucky; and 2Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio * M.S. and D.K. contributed equally to this work. Laser interstitial thermal therapy (LITT) is a minimally invasive stereotactic technique that causes tumor ablation using thermal energy. LITT has shown to be efficacious for the treatment of deep-seated brain lesions, including those near eloquent areas. In this video, the authors present the case of a 62-year-old man with a history of metastatic melanoma who presented with worsening right-sided hemiparesis. MRI revealed a contrast-enhancing lesion in left centrum semiovale in close proximity to corticospinal tracts, consistent with radiation necrosis. The authors review their stepwise technique of LITT with special attention to details for a lesion located near eloquent area. DISCLOSURES Drs. Barnett and Mohammadi report being consultants for Monteris Company.