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Watch the Full Video at https://www.jove.com/v/50470/construc.... Construction of Microdrive Arrays for Chronic Neural Recordings in Awake Behaving Mice - a 2 minute Preview of the Experimental Protocol Eric H. Chang, Stephen A. Frattini, Sergio Robbiati, Patricio T. Huerta North Shore LIJ Health System, Lab of Immune and Neural Networks, Feinstein Institute for Medical Research; Hofstra North Shore LIJ School of Medicine, Department of Molecular Medicine; The design and assembly of microdrives for in vivo electrophysiological recordings of brain signals from the mouse is described. By attaching microelectrode bundles to sturdy driveable carriers, these techniques allow for long-term and stable neural recordings. The lightweight design allows for unrestricted behavioral performance by the animal following drive implantation. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments