NEOPLASIA 5: DEFECTS IN DNA REPAIR, DNA repair genes & Associated Cancers скачать в хорошем качестве

NEOPLASIA 5: DEFECTS IN DNA REPAIR, DNA repair genes & Associated Cancers

In this short tutorial, i have described how defects in DNA repair results in cancer and various DNA repair genes which are involved in the repair of damaged DNA. ***Follow me**** http://ilovepathology.com/ Twitter :   / vijaypatho     / ilovepathology2   Facebook:   / ilovepathology   Defects in DNA repair& Cancer DNA damage is ubiquitous DNA damage is not the same as mutation though it can lead to mutation DNA damage is a chemical alteration ( can be corrected) Mutation is a change in the sequence of base pairs ( cannot be corrected ) If any kind of DNA damage is likely to lead to a mutation, we call it genotoxic There are Mechanisms to repair the types of DNA damage The Effective DNA repair is the backbone of cancer free survival Genome instability is an Important hallmark of cancer INSTABILITY: could be point mutations, trinucleotide repeat expansions and contractions, gene duplications, deletions, and inversions, to large-scale chromosome changes including translocations and whole chromosome gains and losses. DNA repair systems play critical roles in genome stabilization Defects in DNA repair pathways contribute to specific instabilities Erroneous DNA repair leads to mutations or chromosomal aberrations The Genes for DNA repair Individuals with inherited defects in DNA repair genes are at increased risk of developing cancer. Base Excision Pathway (BER):MDB4,Colorectal Ovary Multiple myeloma NER Pathway:XPC, Bladder Skin Cancer Direct reversal of Damage:MGMT,Colon Gastric Glioblastoma Mismatch excision repair (MMR):MSH 6Colorectal Non Homologous End joining: XRCC5, lung Homologous recombination: BRCA 1,Breast Ovary Gastric ~-~~-~~~-~~-~ Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"    • NEOPLASIA 6: WARBURG EFFECT: Hallmark of  ...   ~-~~-~~~-~~-~