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This chapter details various disorders of renal function, encompassing infections, structural issues, and inflammatory diseases. Urinary Tract Infections (UTIs) are commonly caused by E. coli and present classically with urgency, frequency, burning, and cloudy urine. A common painful structural disorder is nephrolithiasis (kidney stones), characterized by severe, intermittent, cramping pain radiating from the flank to the groin, often accompanied by red blood cells in the urine. Inflammatory diseases of the glomerulus covered include focal segmental glomerulosclerosis, IgA nephropathy, and inflammatory processes associated with systemic autoimmune conditions like Lupus nephritis. The chapter also addresses renal neoplasms, including the pediatric cancer Wilm's tumor and adult renal cell carcinoma, discussing their genetic factors and prognosis. 📘 Read full blog summaries for every chapter: https://lastminutelecture.com 📘 Have a book recommendation? Submit your suggestion here: https://forms.gle/y7vQQ6WHoNgKeJmh8 Thank you for being a part of our little Last Minute Lecture family! ⚠️ Disclaimer: These summaries are created for educational and entertainment purposes only. They provide transformative commentary and paraphrased overviews to help students understand key ideas from the referenced textbooks. Last Minute Lecture is not affiliated with, sponsored by, or endorsed by any textbook publisher or author. All textbook titles, names, and cover images—when shown—are used under nominative fair use solely for identification of the work being discussed. Some portions of the writing and narration are generated with AI-assisted tools to enhance accessibility and consistency. While every effort has been made to ensure accuracy, these materials are intended to supplement—not replace—official course readings, lectures, or professional study resources. Always refer to the original textbook and instructor guidance for complete and authoritative information.