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In the high-stakes world of trauma care, managing injuries is a fundamental race against time to prevent the onset of infection. This video provides a concise, evidence-based guide to modern antibiotic prophylaxis, breaking down the critical shift from traditional protocols to new, stewardship-focused mandates. We move from the consensus guidelines for low-risk open fractures to the central dilemma of high-risk, contaminated injuries, comparing the traditional EAST guidelines with the paradigm-shifting 2022 Surgical Infection Society (SIS) recommendations. Learn how to tailor your antibiotic choice based on environmental clues and understand the crucial role of prophylaxis in procedures like chest tube placement. This is your essential update on the precise, evidence-guided application of antibiotics in trauma. (0:00) Introduction: The Race Against Infection (1:02) Part 1: Prophylaxis for Low-Risk Open Fractures (Gustilo-Anderson Type I) (1:37) Standard Protocol: Cefazolin (2:05) Penicillin Anaphylaxis: The Clindamycin Alternative (2:37) Part 2: The Type III Dilemma & The New 24-Hour Rule (2:59) Old vs. New: EAST vs. 2022 SIS Guidelines (3:53) High-Risk Case Study: A Severely Contaminated Fracture (4:54) Part 3: Beyond the Fracture: Tailoring Antibiotics to the Environment (5:14) Specific Contaminants: Soil, Saltwater, & Freshwater (5:39) Special Case: Prophylaxis for Traumatic Chest Tubes (6:55) Part 4: The Modern Mandate for Antimicrobial Stewardship Sources: Gemini (for general information and organization) NotebookLM (for research and information gathering) Manual of Clinical Microbiology by James Versalovic et al. (10th Edition) Manual of Clinical Microbiology by Karen C. Carrol et al. (12th Edition) #TraumaSurgery #Antibiotics #AntimicrobialStewardship #MedicalEducation #FOAMed #EmergencyMedicine #Orthopedics #InfectiousDisease #GustiloAnderson #OpenFracture #SurgicalInfectionSociety #EASTGuidelines #Cefazolin #Clindamycin #ClinicalGuidelines #TraumaCare #Surgery #MedicineExplained