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Differentiating Cardiac vs. Respiratory Causes of Dyspnea Using NT-proBNP Dyspnea (shortness of breath) is a common clinical symptom with multiple causes. A key challenge is distinguishing between cardiac and respiratory origins. NT-proBNP (N-terminal pro-brain natriuretic peptide) is a valuable biomarker that helps in this differentiation. How NT-proBNP Helps in Diagnosis? 1️⃣ Normal NT-proBNP → Likely Respiratory Cause If NT-proBNP levels are within the normal range, a cardiac cause is less likely. Consider respiratory conditions such as COPD, asthma, pneumonia, or pulmonary embolism. 2️⃣ Elevated NT-proBNP → More in Favor of Cardiac Cause High levels suggest increased cardiac wall stress, commonly seen in heart failure, myocardial infarction, or valvular heart disease. Helps in distinguishing cardiogenic pulmonary edema from non-cardiogenic causes. 3️⃣ Additional Clinical Correlation is Essential Always interpret NT-proBNP levels along with patient history, clinical examination, and other investigations (ECG, echocardiography, chest X-ray). Conditions like renal dysfunction, sepsis, and older age can also raise NT-proBNP levels, so a holistic approach is necessary. 🔍 Key Takeaway: NT-proBNP normal? Think respiratory cause. NT-proBNP high? Think cardiac cause. Always correlate clinically for accurate diagnosis. #Dyspnea #NTproBNP #HeartFailure #COPD #Cardiology #Pulmonology #MedicalEducation