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In this radiology lecture, we review the ultrasound appearance of giant cell tumor of the tendon sheath! Key teaching points include: 1) AKA tenosynovial giant cell tumor, localized nodular tenosynovitis 2) 2nd most common mass of hand & wrist after ganglion cyst 3) Most common at volar aspect of first 3 digits. Less commonly at wrist, ankle, foot, knee 4) On ultrasound, usually homogeneously hypoechoic with well-defined lobulated margins 5) Closely associated with tendon, but will not move with tendon = Arises from tendon sheath, not tendon itself 6) May show posterior acoustic enhancement, but internal vascular flow typically present 7) Usually benign. Can be locally aggressive, rarely malignant. Tx: Surgical excision 8) Fibroma of the tendon sheath has a similar ultrasound appearance and location but is less common. Benign. Tx: Surgical excision References: 1) Middleton WD, Patel V, Teefey SA, Boyer MI. Giant cell tumors of the tendon sheath: analysis of sonographic findings. AJR Am J Roentgenol. 2004;183(2):337-339. To learn more about the Samsung RS85 Prestige ultrasound system, please visit: https://www.bostonimaging.com/rs85-pr... Click the YouTube posts tab or follow on social media for bonus teaching material posted throughout the week! Website: https://Radquarters.com/ Spotify Video Podcast: https://spoti.fi/462r0F2 Apple Video Podcast: https://apple.co/3ZhHuGu Instagram: / radquarters Facebook: / radquarters X (Twitter): / radquarters Reddit: / radiologisthq This video is for informational purposes only. It does not replace the advice or counsel of a doctor or health care professional.