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Fungal infections on penis are not so common and even if they occur, pustules are not very frequent. Whenever you see a pustule on penis, it is better to check with a dermatologist to know what exactly it is. It can be a bacterial infection just like a bill or some serious sexually transmitted infections which can be there for a long time. Viral infection can also present with pustules. Herpes infection, herpes zoster infection , or molluscum can also cause a pustule. When you are suspecting it as a Fungal infection, and you are using all the antifungals and if it is not responding, it is better to rule out other infections, either bacterial o viral or very rarely a resistant fungal infection. Very rarely a non-athropophilic fungal infection, means infections that are not actually seen on humans. If that type of a fungus infects human beings, in those infections the inflammation is more and they can get pustules. Because they are more inflammatory and they are not so common, they are resistant to topical treatments alone. In these situations, we treat with systemic anti-fungal agents, that means you have to take a tablet or capsule daily for few weeks. That will help you to cure it. When you are not responding to regular treatments, it is better to consult dermatologist.