Long Covid Research: Microclots скачать в хорошем качестве

Long Covid Research: Microclots

In my first video about research behind #LongCovid, I am covering Microclots, one of the main theories behind Long-Covid. Since I have filmed this video microclots have been featured in National Geographic in a very nice and very summary article: https://www.nationalgeographic.com/ma... References Review describing how microclots are composed amongst other properties [1] Kell, et al. Biochemical Journal (2022): A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications. https://doi.org/10.1042/BCJ20220016 First case report of microclots in acute covid [2] Pretorius, et al. Cardiovascular Diabetology (2020): Prevalence of readily detected amyloid blood clots in ‘unclotted’ Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report. https://doi.org/10.1186/s12933-020-01... First identification of microclots in #LongCovid across a cohort of patients with 4 groups (LongCovid, covid, diabetes type II, healthy): [3] Pretorius, et al. Cardiovascular Diabetology (2021) Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin. https://doi.org/10.1186/s12933-021-01... Replication study with 80 Long Covid patients: [4] Pretorius, et al. (2022) Cardiovascular Diabetology Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC) https://doi.org/10.1186/s12933-022-01... Potential mechanism through which microclots may contribute to post-exertional symptom exacerbation (PESE): [5] Kell and Pretorius (2022) Biochemical Journal The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications. https://doi.org/10.1042/BCJ20220154 Two cases of indirect evidence: in a 14 year-old adolescent, lungs shown structurally fine but microthrombi hypothesized to block passage of oxygen from lung to blood causing breathlessness [6] Buonsenso, et al. (2021) The Lancet Child & Adolescent Health Evidence of lung perfusion defects and ongoing inflammation in an adolescent with PASC https://doi.org/10.1016/S2352-4642(21... MRI in 34 Long-Covid patients using a gas (Xenon) that behaves like oxygen also shows gas is not absorbed normally even though lungs don’t have structural damage [7] Matheson, et al. (2022) Radiology Persistent Xenon-MRI Pulmonary and CT vascular abnormalities in symptomatic individuals with PASC https://doi.org/10.1148/radiol.220492 Spike protein causes microclots: [8] Grobbelaar, et al. (2021) Bioscience reports SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in covid-19 https://doi.org/10.1042/BSR20210611 This process is worse for earlier variants as compared to omicron: [9] Grobbelaar, et al. (2022) Seminars in Thrombosis and Hemostasis Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is (…) https://doi.org/10.1055/s-0042-1756306 [10] search for her twitter page and look through post OR on the search bar of twitter right: from: @organichemusic natto That will give you the threads in which she has talked about nattokinase and the surveys she has conducted [11] Gez Medinger interviews with Resia Pretorius and Douglas Kell: Part 2:    • 'Microclots' in Long Covid: The Latest Res...   Part 3:    • How 'Microclots' Fit Into the Long Covid P...   Part 4, on potential treatments:    • How To Treat 'Microclots' in Long Covid | ...   Part 5, on nattokinase:    • Can Nattokinase Help Break Down 'Microclot...   [12] The Long Covid sessions, interviews: Resia Prerotius (episode 18): https://www.tlcsessions.net/episodes/... Douglas Kell (episode 44): https://www.tlcsessions.net/episodes/...