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In this episode of The Nucleus by Regeneron, Henry Wei, MD, Head of Development Innovation at Regeneron, speaks with Ken Getz, Executive Director of the Tufts Center for the Study of Drug Development, Research Professor and Founder and Board Chair of CISCRP, about the growing complexity of clinical trial protocols and the need to balance scientific rigor with operational efficiencies. Ken shares how collaboration and benchmarking can help clinical trial sponsors better understand and reduce the burden of their studies. The conversation also explores how advances in AI and digital tools are streamlining trial design and execution. Together, they offer practical solutions for designing studies that are both efficient and less burdensome for sites and participants. Stay tuned for future episodes from rotating hosts at Regeneron.