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Antisocial Personality Disorder belongs in a class of conditions manifest by dramatic, emotional and unpredictable behavior. Once referred to as psychopaths or sociopaths, the exact boundaries of each of these conditions remains under review. Individuals with the Antisocial Personality Disorder are manipulative, seductive, glib, and deceitful. They are dishonest, callus, lack remorse or guilt, become nasty or vengeful in response to minor slights may be aggressive or sadistic. Anger frequently is manifest. They fail to honor their financial obligations or commitments, act impulsively without considering the possible effects and engage in risky behaviors. People with Antisocial Personality Disorder frequently become bored and irritated, lack empathy, appear incapable of sustained intimate relationships, dominate others, seek personal gratification, may perform violent or illegal activities, are irritable and egocentric. They lie without guilt or remorse and manipulate others for personal gain. Men are more frequently affected than women by a factor of 3-5 fold. Diagnosis is restricted to adults. During the childhood years, Conduct Disorder presages the later development of Antisocial Personality Disorder. These individuals appear at heightened risk for accidents, traumatic injuries, suicide and infectious diseases including hepatitis C and HIV. Treatment for the Antisocial Personality Disorder remains inadequate. Some therapies may assist in the wide array of other psychiatric disorders that often accompany this disorder. These include bipolar disorder, borderline personality disorder, depression, anxiety and substance use. Narcissistic Personality Disorder shares some symptoms with the Antisocial Personality Disorder.