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Welcome back to Science at the Source! 🎙️ In this episode, Dr. Hilary Marusak sits down with Rodrigo M. Klein, PhD — Postdoctoral Scholar in the Piomelli Lab at UC Irvine — to unpack how cannabis, and specifically THC, affects the developing brain. Dr. Klein’s research bridges cellular, molecular, and behavioral levels to shed light on how substances alter neurodevelopment, with implications for cognition, psychiatric vulnerability, and public health. In this conversation, they explore: • How THC exposure interacts with key stages of brain development, from fetal life to adolescence • Why adolescence is such a sensitive window for both risk and resilience • The role of microglia and the endocannabinoid system in shaping neurodevelopmental outcomes • How environmental and social contexts influence substance use and brain health • Dr. Klein’s scientific journey — from Brazil to UC Irvine — and what motivates his focus on cannabinoids • His vision for the next decade of research on THC, neurodevelopment, and translational science Don’t miss this timely discussion with one of the next generation’s leading voices in cannabis and brain research, connecting basic neuroscience to urgent public health questions. 👉 Follow us on Instagram (@uci_cannabis), LinkedIn, and Bluesky (@ucicannabis.bsky.social) 🎧 More episodes: / @ucicenterforthestudyofcann5100 Keywords THC, cannabis, marijuana, neurodevelopment, adolescence, brain development, cognition, psychiatric risk, substance use disorder, endocannabinoid system, microglia, neuroscience, UC Irvine, Rodrigo Klein, Science at the Source