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Effects of Ovarian Failure on Muscle Form and Function

Utilizing an occupational chemical called VCD, which induces gradual ovarian failure, Parastoo’s work offers a nuanced perspective on the time-course changes in muscle function throughout menopause. She discusses her findings on the contractile properties of skeletal muscles at the single fiber level as well as explores morphological alterations, particularly focusing on fatty infiltration and fibrosis in muscles post-ovarian failure, which will have implications on overall muscle health and function. This session also highlights the broader implications of these changes, emphasizing the importance of studying the perimenopause phase. Parastoo discusses how understanding the physiological changes during this critical transitional phase can lead to potential strategies for mitigating the negative effects of menopause on women’s health.