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This webinar focuses on the role of HIPEC to prevent metachronous or treat synchronous peritoneal colorectal metastases. Several attempts have been made to prevent peritoneal metastases in advanced colonic cancer. Recently, the Spanish T4 trial was published which showed the preventative effect of surgery and HIPEC on peritoneal recurrence. Dr Arjona-Sanchez is the PI of the study and expert in this field. When colorectal cancer with synchronous peritoneal metastases is diagnosed, there are many challenges related to what to do and what not to do. Dr de Hingh is an international expert who shares a case and his view on the role of HIPEC in this field. Moderators Andreas Brandl, Heidelberg University Hospital, Heidelberg, NL Niels Kok, National Cancer Institute, Amsterdam, NL Helen Mohan, Peter MacCallum Cancer Center, Sydney, AU Speakers Alvaro Arjona, Hospital Universitario Reina Sofía, Córdoba, SP Ignace de Hingh, Catharina Ziekenhuis, Eindhoven, NL Discussion on two cases including a patient at high risk of colorectal peritoneal metastases and a patient with synchronous colorectal peritoneal metastases.