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This video includes answers to five questions about Serotonin Modulators and is intended for psychiatrists and psychiatry residents. Questions: 1. What is the most common comorbidity with depressive disorders? 2. Name a new antidepressant that can be used for the treatment of depression and comorbid anxiety? 3. Name an antidepressant that improves cognitive function independent of improvement in depressive symptoms? 4. Name four antidepressants that you can use for patients who are concerned about sexual side effects? 5. Compare the mechanisms of action of serotonin modulators (Trazodone, Vilazodone, Vortioxetine)? Please note: This channel does NOT contain any medical advice. Please reach out to your psychiatrist or your primary care provider if you have any questions about your mental health or your medications. References: 1) Krasuski, J. Beat the Boards Psychiatry Initial Certification Review Lectures. Lecture 02B: Depressive Disorders II: Diagnosis and Assessment Part 2 and Lecture 02C: Depressive Disorders III: Treatment Part I 2) Stahl, S. M., Grady, M. M., & Muntner, N. (2014). Stahl's essential psychopharmacology: Prescriber's guide. 3) Jacobsen PL, Nomikos GG, Zhong W, Cutler AJ, Affinito J, Clayton A. Clinical implications of directly switching antidepressants in well-treated depressed patients with treatment-emergent sexual dysfunction: a comparison between vortioxetine and escitalopram. CNS Spectr. 2020;25(1):50-63.